No

Module Name

Identification and Separation of Active Pharmaceutical Ingredients Practice

1

Code of Subjects

P10A02.0211

2

Study load

1(0-1) credits

Contact hour per semester: 45

Total workload : 45

3

Semester

2

4

Precondition

There is no

5

Competence

After following this practicum course, 

1. Able to understand and explain the selection of compound identification methods 
2. Able to explain reactions in compound identification based on specific reactions on inorganic salt compounds and based on functional groups 
3. Able to explain methods for conducting purity tests with water content and melting point, heavy metal limit tests
4. Able to understand and explain methods of separating compounds according to specific reactions and functional groups. 
5. Able to understand and explain separation methods for analytical purposes.

6

Elements of Competency

MKB

7

Type Competency

Main competence

8

Syllabus

This course explains the scope, the basics of qualitative analysis (physical and chemical methods) and the basics of separation, identification of anion cations, identification of inorganic salts, analysis of drug class alcohols, phenols, carboxylic acids, nitrogen compounds, antihistamines, sulfonamides, barbiturates, antibiotics, Compendial method for qualitative testing, Determination of moisture content by Karl Fischer, gravimetry, Purity test: melting point, heavy metal limit test, Size separation methods: filtration, dialysis; density: centrifugation, separation method based on physical state changes: distillation, sublimation, recrystallization; partition: ECC, Principles of simple chromatography: thin layers and paper, Principles of simple chromatography: columns and densitometry.

9

Attribute Soft Skill

Ethics, awareness, discipline

10

Learning methods

Lab. practice, presentation, lecturer, discussion, project

11

Learning Media

Lab. equipment and LCD Projector

12

Appraisal

Quiz : 20%

Assignment : 20% 

UTS : 30%

UAS : 30%

13

Lecturer

Dr. apt. Ida Musfiroh, M.Sc., Dr. apt. Nyi Mekar Saptarini, M.Si, and Dr. apt. Rimadani Pratiwi, M.Sc.

14

References

1. Skoog DA, Holler FJ, Crounch SR. Principles of instrumental analysis. Australia: Cengage Learning. 2018.
   
2. Pedersen-Bjergaard S,  Gammelgaard B, Halvorsen TG. Introduction to pharmaceutical analytical chemistry. NJ : Wiley, 2019.
   
3. Rao DM, Swamy AVN, Reddy DH. Instrumental methods of analysis. Kindle ed. CBS Publishers Ltd. 2020.