Prof. Jutti Levita, M.Si
A. PERSONAL
| Name | : | Prof. Dr. Jutti Levita, M.Si. |
| Date & place of birth | : | Surabaya, 9 April 1963 |
| Affiliation | : | Department of Pharmacology and Clinical PharmacyFaculty of Pharmacy, Universitas Padjadjaran |
| Address | : | Jl. Raya Bandung-Sumedang km 21Sumedang 45363 West Java, Indonesia |
| Email address | : | [email protected] |
| Position | : | Lecturer |
| Expertise | : | Molecular pharmacology, drug discovery |
B. Education
| 1980 – 1986. | : | Bachelor of Pharmacy, Faculty of Mathematics and Natural Sciences,Universitas Padjadjaran |
| 1997 – 1999 | : | Master of Science, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, bandung Institute of Technology (ITB) |
| 2007 – 2011 | : | Doctor in Pharmacy, School of Pharmacy, Bandung Institute of Technology (ITB) |
C. Organization
1. Indonesian Association of Scientific Journal Editors (membership No. EBII-2019-0091)
2. Indonesian Medicinal Chemists Association (membership No. 16)
D. Research & Research Grant (in the last 5 years)
| No | Year | Topic | Position | Funding Organization |
| 1 | 2009-2010 | Pengembangan Andrografolid dari Herba Sambiloto (Andrographis paniculata (Burm.F) Nees) sebagai Kandidat Obat Anti-HIV melalui Mekanisme Inhibisinya Pada Molekul Nuclear Factor- Kappa B | PrincipalInvestigator | Hibah Bersaing dari Proyek Pengkajian Penelitian Pendidikan Tinggi, Dikti |
| 2 | 2015-2016 | Telaah Penghambatan Andrografolid terhadap Enzim Siklooksigenase Melalui Reaksi Michaelis-Menten Untuk Pencarian Obat Antiinflamasi | PrincipalInvestigator | Hibah Kompetensi dari Proyek Pengkajian Penelitian Pendidikan Tinggi, Dikti |
| 3 | 2015 | Pengembangan Ekstrak Terstandar Jawer Kotok (Plectranthus scutellarioides) untuk Sediaan Anti-inflamasi dan Penyakit Gangguan Metabolik | Co-investigator | Academic-Leadership Grant dari Universitas Padjadjaran |
| 4 | 2016-2017 | Aktifitas dan mekanisme antikanker dari sulforaphane sebagai terapi adjuvant baru dalam manajemen terapi kanker payudara | Co-investigator | Hibah Penelitian Tim Pasca Sarjana dari Simlitabmas Kemenristekdikti |
| 5 | 2017 | Profil Ekspresi Protein, Farmakodinamik, dan Farmakokinetik Herbal Indonesia | PrincipalInvestigator | Academic-Leadership Grant dari Universitas Padjadjaran |
| 6 | 2018-2019 | Mekanisme Molekular Herbal Berkhasiat Antiinflamasi serta Profil Enzim Pengkatalisis Flavonoidnya | PrincipalInvestigator | Academic-Leadership Grant dari Universitas Padjadjaran |
| 7 | 2019 | Mekanisme Antiinflamasi Ekstrak Boesenbergia rotunda melalui Penghambatan Inducible Nitric Oxide Synthase dan Ekspresi NF-ƙB | PrincipalInvestigator | Penelitian Disertasi Doktor dari Simlitabmas Kemenristekdikti |
| 8 | 2019-2020 | Over-Ekspresi Gen crtYB pada Biosintesis Astaxanthin di dalam Mikroalga Haematococcus pluvialis untuk Penghambat Gejala Mild Cognitive Disorder | Co-investigator | Hibah Penelitian Kerjasama Antar Perguruan Tinggi dari Simlitabmas Kemenristek |
| 9 | 2020 | Penapisan Farmakofor dan Penambatan Molekul Senyawa Lakton Diterpen Tanaman Andrographis paniculata pada Domain Peptidase Angiotensin-Converting Enzyme 2 Manusia (hACE2) untuk Pencarian AntiCOVID-19 | PrincipalInvestigator | Hibah Riset Data Pustaka dan Daring dari Universitas Padjadjaran |
| 10 | 2020 | Farmakologi Tanaman Antiinflamasi | Co-investigator | Hibah Penulisan Buku dari Universitas Padjadjaran |
| 11 | 2021-2022 | Development of smart-phone application technology to improve treatment adherence for TB patients in Indonesia | Co-investigator | Southeast Asia-Europe Joint Funding Scheme for Research and Innovation |
| 12 | 2021-2022 | Pengembangan Teknologi Aplikasi Smart-Phone untuk Peningkatan Kepatuhan Pasien pada Terapi Tuberkulosis di Indonesia | Co-investigator | Hibah Penelitian Terapan dari Simlitabmas Kemenristek |
| 13 | 2020-2022 | Farmakologi Molekular Tanaman Obat untuk Pengembangan Fitofarmaka dan Pangan Fungsional serta Peningkatan Kualitas Hidup Masyarakat | PrincipalInvestigator | Academic-Leadership Grant dari Universitas Padjadjaran |
E. Publications in the last 5 years
(h-index GoogleScholar: 10; h-index Scopus: 5)
| No | Publication |
| 1 | Yuniarti Falya, Deni Firmansyah, Nyi Mekar Saptarini, Yuli Andriani, Sri Adi Sumiwi, Jutti Levita*. The active site of human tyrosinase-related protein: Can it be inhibited by plants? Accepted in Journal of Advanced Pharmacy Education & Research 2021; |
| 2 | Renny Amelia, Nyi Mekar Saptarini, Eli Halimah, Yuli Andriani, Aliya Nurhasanah, Jutti Levita, Sri Adi Sumiwi. Pharmacology activities and extraction of α-chitin prepared from crustaceans: A review. Journal of Applied Pharmaceutical Science 2020; 10(12): 140-149. DOI: 10.7324/JAPS.2020.101218 |
| 3 | Chandra Agung Purnama, Indriyanti Rafi Sukmawati, Jutti Levita. Updates on the potential role of immune checkpoints sPD-1 and sPD-L1 in the stratification of many diseases. Current Trends in Immunology 2020; 21: 53-77. |
| 4 | Aziiz Mardanarian Rosdianto, Irma Melyani Puspitasari, Ronny Lesmana, Jutti Levita*. Bioactive compounds of Boesenbergia sp. and their anti-inflammatory mechanism: A review. Journal of Applied Pharmaceutical Science 2020; 10(7): 116-126. DOI: http://dx.doi.org/10.7324/JAPS.2020.10715 |
| 5 | Sandra Megantara, Mutakin Mutakin, Eli Halimah, Ellin Febrina, Jutti Levita*.Molecular interaction of the downstream executioner cysteine aspartyl proteases (caspase-3 and caspase-7) with corilagin, quercetin, rutin, kaempferol, gallic acid, and geraniin of Acalypha wilkesiana Müll.Arg. Rasayan Journal of Chemistry 2020; 13(3): 1321-1329. DOI: http://dx.doi.org/10.31788/%20RJC.2020.1335766 |
| 6 | Mutakin Mutakin, Tanti Juwita, Sandra Megantara, Irma Melyani Puspitasari, Jutti Levita*. Determination of quercetin and rutin in the ethyl acetate fraction of Etlingera elatior (Jack) R.M. Smith flower by reversed-phase liquid chromatography-mass spectroscopy. Rasayan Journal of Chemistry 2020; 13(3): 1379-1385. DOI: http://dx.doi.org/10.31788/RJC.2020.1335723 |
| 7 | Tanti Juwita, Irma Melyani Puspitasari, Jutti Levita*. The anti-inflammatory activity of the flower of Etlingera elatior (Jack) R.M. Smith on gastric ulceration-induced Wistar rats. Pakistan Journal of Biological Sciences 2020; 23(9): 1193-1200 DOI: https://doi.org/10.3923/pjbs.2020.1193.1200 |
| 8 | Aziiz Mardanarian Rosdianto, Irma Melyani Puspitasari, Ronny Lesmana, Jutti Levita*. Inhibitory activity of Boesenbergia rotunda (L.) Mansf. rhizome towards the expression of Akt and NF-kappaB p65 in acetic acid-induced Wistar rats. Evidence-Based Complementary and Alternative Medicine 2020; 2020. Article ID 6940313. DOI: https://doi.org/10.1155/2020/6940313 |
| 9 | Juwita Ramadhani, Mutakin Mutakin, Dyah Aryani Perwitasari, Jutti Levita*. Quality of life of patients receiving a single or combination of calcium channel blocker-angiotensin receptor blocker: A cross-sectional study in West Java, Indonesia. Journal of Applied Pharmaceutical Science 2020; 10(3): 88-92. DOI: http://dx.doi.org/10.7324/JAPS.2020.103011 |
| 10 | Aziiz Mardanarian Rosdianto, Irma Melyani Puspitasari, Ronny Lesmana, Jutti Levita*. Determination of quercetin and flavonol synthase in Boesenbergia rotunda rhizome. Pakistan Journal of Biological Sciences 2020; 23(3):264-270. DOI: http://dx.doi.org/10.3923/pjbs.2020.264.270 |
| 11 | Diah Lia Aulifa*, I Ketut Adnyana, Jutti Levita, Sukrasno Sukrasno. Updates on 4-hydroxyderricin and xanthoangelol of angelica plants: Extraction and pharmacological activities. Rasayan Journal of Chemistry 2020; 13(1):11-17. DOI: http://dx.doi.org/10.31788/RJC.2020.1315397 |
| 12 | Diah Lia Aulifa*, I Ketut Adnyana, Jutti Levita, Sukrasno Sukrasno. 4-Hydroxyderricin isolated from the sap of Angelica keiskei Koidzumi: Evaluation of Its Inhibitory Activity towards Dipeptidyl Peptidase-IV. Scientia Pharmaceutica 2019; 87(4): 30. DOI: https://doi.org/10.3390/scipharm87040030 |
| 13 | Titin Sulastri, Marleen Sunyoto, Marvel Reuben Suwitono, Jutti Levita*. The preparation and storage time of red ginger (Zingiber officinale var. Rubrum)-supplemented bread. Journal of Advanced Pharmacy Education and Research 2019; 9(3): 109-114. |
| 14 | Hanny Nugrahani, Arif S.W. Kusuma*, Jutti Levita, Rizky Abdulah. Synergistic combination of sulforaphane and methylseleninic acid in inhibiting the proliferation of MCF-7 breast cancer cells. International Journal of Cancer Research 2019 online first |
| 15 | Sri Adi Sumiwi*, Ade Zuhrotun, Rini Hendriani, Mochamad Rizal, Jutti Levita, Sandra Megantara. Subchronic toxicity of ethanol extract of Syzygium polyanthum(Wight) Walp. leaves on Wistar rat. The Indonesian Biomedical Journal 2019; 11(1): 30-35. DOI: https://doi.org/10.18585/inabj.v11i1.458 |
| 16 | Jutti Levita*, Recky Patala, Jennifer Kolina, Tiana Milanda, Mutakin Mutakin, Irma Melyani Puspitasari, Nyi Mekar Saptarini, Sri Adi Sumiwi. Pharmacophore modelling and molecular docking of phytoconstituents in Morus sp. and Arcangelisia flava against nitric oxide synthase for antiinflammatory discovery. Journal of Applied Pharmaceutical Science 2018;8(12):53-59. DOI: 10.7324/JAPS.2018.81207 |
| 17 | Jutti Levita*, Dina Mulyana Syafitri, Rini Daud Supu, Mutakin Mutakin, Sandra Megantara, Maya Febrianti, Ajeng Diantini. Pharmacokinetic study of 10-gingerol and 6-shogaol in the plasma of healthy subjects treated with red ginger (Zingiber officinalevar. Rubrum) suspension. Biomedical Reports 2018; 9(6): 474-482. DOI: 10.3892/br.2018.1163 |
| 18 | Tanti Juwita*, Irma Melyani Puspitasari, Jutti Levita. Torch ginger (Etlingera elatior): A review on its botanical aspects, phytoconstituents and pharmacological activities. Pakistan Journal of Biological Sciences 2018; 21(4): 151-165. DOI: 10.3923/pjbs.2018.151.165 |
| 19 | Steffi Liem, Tina Rostinawati, Ronny Lesmana, Sri Adi Sumiwi, Tiana Milanda, Mutakin Mutakin, Irma Melyani Puspitasari, Jutti Levita*. Modulation of caspase-3 expression by Arcangelisia flava post acetaminophen-induced hepatotoxicity in rat’s liver. The Indonesian Biomedical Journal 2018; 10(2): 148-155. DOI: 10.18585/inabj.v10i2.412 |
| 20 | Sandra Megantara, Halimah Halimah, Annisa Putrianty, Daryono Hadi Tjahjono, Rahmana Emran Kartasasmita, Maria Immaculata Iwo, Jutti Levita*, Slamet Ibrahim. Microwave-assisted synthesis of hydroxybenzylidene-andrographolides and its inhibitory activity against HIV-1 protease. Journal of Applied Pharmaceutical Science 2018; 8(3): 9-13. DOI: 10.7324/JAPS.2018.8302 |
| 21 | Sandra Megantara, Agung Yodha Mw, Sahidin I, Ajeng Diantini, Jutti Levita*. Pharmacophore screening and molecular docking of phytoconstituents in Polygonum sagittatum for cyclooxygenase-2 inhibitors discovery. Asian Journal of Pharmaceutical and Clinical Research 2018; 11(1): 83-88. DOI: 10.22159/ajpcr.2018.v11i1.21154 |
| 22 | Jutti Levita*, Muhammad R. Rositama, Nazura Alias, Nurul Khalida, Mekar Saptarini, Sandra Megantara. Discovering COX-2 Inhibitors from Flavonoids and Diterpenoids. Journal of Applied Pharmaceutical Science 2017; 7(7): 103-110. DOI: 10.7324/JAPS.2017.70716 |
| 23 | Jutti Levita*, Muhammad R. Rositama, Nazura Alias, Nurul Khalida, Mekar Saptarini, Sandra Megantara. Discovering COX-2 Inhibitors from Flavonoids and Diterpenoids. Journal of Applied Pharmaceutical Science 2017; 7(7): 103-110. DOI: 10.7324/JAPS.2017.70716 |
| 24 | Jutti Levita*, Tanti Juwita, Selma Ramadhani, Nyi Mekar Saptarini, Mutakin Mutakin. Chromatogram profiles of andrographolide in A23187-induced New Zealand rabbit’s urine and faeces. Journal of Applied Pharmaceutical Science 2017; 7(1): 156-159. DOI: 10.7324/JAPS.2017.70121 |
| 25 | Sandra Megantara, Maria Immaculata Iwo, Jutti Levita*, Slamet Ibrahim. Determination of ligand position in aspartic proteases by correlating Tanimoto coefficient and binding affinity with Root Mean Square Deviation. Journal of Applied Pharmaceutical Science 2016; 6(1): 125-129. DOI: 10.7324/JAPS.2016.600120 |
| 26 | Athina Mardhatillah, Mutakin Mutakin, Jutti Levita*. FeCl3-catalyzed synthesis of dehydrodiisoeugenol. International Journal of Chemistry 2016; 8(1): 1-7. DOI: 10.5539/ijc.v8n1p1 |
| 27 | Siswandi, Mutakin, Jutti Levita*. Virtual screening of co-formers for ketoprofen co-crystallization and the molecular properties of the co-crystal. Journal of Applied Pharmaceutical Science 2015; 5(6): 78-82. DOI: 10.7324/JAPS.2015.50613 |
| 28 | Jutti Levita*, Laura K. Wijaya, Sharren Celcilia, dan Mutakin. Inhibitory activity of Kaempferia galanga and Hibiscus sabdariffa on the rate of PGH2 formation. Journal of Applied Sciences 2015; 15(7): 1032-1036. DOI: 10.3923/jas.2015.1032.1036 |
| 29 | Hardiani Rahmania, Abdul Mutalib, Martalena Ramli, Jutti Levita*. Synthesis and stability test of Radiogadolinium (III)-DOTA-PAMAM G3.0-trastuzumab as SPECT-MRI molecular imaging agent for diagnosis of HER-2 positive breast cancer. Journal of Radiation Research and Applied Sciences2015;8(1): 91-99. DOI:https://doi.org/10.1016/j.jrras.2014.12.001 |
| 30 | Devinna Kang, Mutakin, Jutti Levita*. Computational study of triterpenoids of Ganoderma lucidum with aspartic protease enzymes for discovering HIV-1 and plasmepsin inhibitors. International Journal of Chemistry 2015; 7(1): 62-68. DOI: 10.5539/ijc.v7n1p62 |
F. SCIENTIFIC MEETINGS AS A SPEAKER IN THE LAST 5 YEARS
| No | Name of the Conference | Title of Presentation | Time and Place |
| 1 | Bandung International Conference on Medicinal Chemistry | Computational study and labeling of andrographolide with 131Iodine for inflammatory radiotracer | ITB, August 2009 |
| 2 | The 1st International Conference on Computation for Science and Technology | Molecular modeling study of andrographolide, neoandrographolide, thymoquinone, thymoquinole, gallic acid, and aurine tricarboxylic acid, inhibitors of NF-kappaB | Chiang Mai, Thailand,August 2010 |
| 3 | International Conference on Mathematics and Natural Sciences | Vinyl bromination of andrographolide | ITB,November 2010 |
| 4 | The 2nd International Conference on Computation for Science and Technology | A molecular modeling study on PPAR-γ agonists binding mode | Nigde, TurkeyJuly 2012 |
| 5 | The 5th Computer-Aided Drug Design | Density functional theory calculations of proton affinities for simple organic compounds and drug-like molecules | ITB,December 2013 |
| 6 | The 3rd International Conference on Computation for Science and Technology | Inhibitors of tyrosinase enzyme and alpha-melanocyte stimulating hormonefrom Zingiberaceae plants for depigmentation agent discovery | Denpasar,September 2014 |
| 7 | The 10th AFMC International Medicinal Chemistry Symposium (AIMECS 2015) | Inhibitory activity of andrographolide and andrograpanin on the rate of PGH2formation | Jeju, Korea,October 2015 |
| 8 | The 7th Computer-Aided Drug Design (invited speaker) | Cyclooxygenase inhibitors: A perspective from in silico study | Penang, Malaysia,Desember 2015 |
| 9 | European Congress on Pharmacology | Bioavailability and metabolism products of andrographolide in A23187 induced-rabbit | Istanbul, Turkey,June 2016 |
| 10 | The International Conference on Pharmacology and Clinical Pharmacy 2016 | Pharmacological activities of Plecranthus scutellarioides leaves extract | Bandung, September 2016 |
| 11 | The 2nd Indonesian Conference on Clinical Pharmacy | The correlation of hypertension risk factors with sodium and potassium levels in urine | Bali, October 2016 |
| 12 | The 2nd International Seminar and Expo on Jamu (ISEJ) | Drug hepatotoxicity and plants hepatoprotective activity: A review | Bandung, September 2017 |
| 13 | The 2nd International Conference in Medicinal Chemistry (invited speaker) | Discovering COX-2 inhibitors: from in silico pharmacology to animal study | Bandung, October 2017 |
| 14 | Bandung International Conference on Collaborative Pharmacy Research | Inhibition of nitric oxide synthase by Gynura procumbens and Ageratumconyzoides | Bandung, April 2018 |
| 15 | The 2nd International Conference of Pharmacy and Health Sciences (invited speaker) | Plants hepatoprotective activity: Cross talk in drug discovery | Ipoh, Malaysia,September 2018 |
G. REVIEWER/EDITOR
| a. Scientific Journal | |
| No | Position and Journal |
| 1 | Editor in Chief at Pharmacology and Clinical Pharmacy Research http://jurnal.unpad.ac.id/pcpr/about/editorialTeam |
| 2 | Peer-reviewer at Jurnal Sains Farmasi & Klinis http://jsfk.ffarmasi.unand.ac.id/index.php/jsfk/about/displayMembership/8 |
| 3 | Peer-reviewer at Jurnal Fitofarmaka https://journal.unpak.ac.id/index.php/fitofarmaka/about/displayMembership/79 |
| 4 | Peer-reviewer at Jurnal Farmasi Klinik Indonesia http://ijcp.or.id/ |
| 5 | Peer-reviewer at Journal of Applied Pharmaceutical Science http://www.japsonline.com/ |
| 6 | Peer-reviewer at The Indonesian Biomedical Journal https://inabj.org/index.php/ibj |
| 7 | Peer-reviewer at Toxicological Research http://www.toxicolres.org/main.html |
| 8 | Peer-reviewer at Oncology Letters https://www.spandidos-publications.com/ol |
| 9 | Peer-reviewer at Molecular Medicine Reports https://www.spandidos-publications.com/mmr |
| 10 | Peer-reviewer at Experimental and Therapeutic Medicine https://www.spandidos-publications.com/etm |
| 11 | Peer-reviewer at Evidence-Based Complementary and Alternative Medicine (eCAM) https://www.hindawi.com/journals/ecam/about/ |
| b. Research Proposal | ||
| No | Organization | Year |
| 1 | DIKTI | 2017 – present |
| 3 | UNPAD | 2017 – present |
H. BOOKS IN THE LAST 5 YEARS
| No | Title | Publisher | ISBN | Year |
| 1 | Pemodelan Molekul dalam Kimia Medisinal | Graha Ilmu | 978-979-756-832-0 | 2011 |
| 2 | Radioiodinasi pada Pembuatan Radiofarmaka | DeePublish | 602280909-8 | 2013 |
| 3 4 5 6 | Andrografolid sebagai Inhibitor Enzim SiklooksigenasePerspektif Molekular Aktivitas Antiinflamasi Tanaman Kecombrang (Etlingera elatior Jack RM Smith)Menanam dan Memanfaatkan Jahe Merah sebagai Pangan FungsionalBioprospeksi Sumber Daya Hayati: Sebuah Perspektif Multidisiplin | Unpad Press DeePublish DeePublish Unpad Press | 978-602-6308-89-4978-623-209-213-6 978-623-209-213-6 | 2016 2019 2020 2020 |
