Course Information
Course Semester Plan
Course Information
| No | Module name | Drug Discovery and Development |
| 1 | Courses code | P20.02003 |
| 2 | Study loads | 3 credits |
| 3 | Semester | Second Semester |
| 4 | Precondition | there is no |
| 5 | Competence | 1. Upon completion of this course, students are expected to be able to: 2. List and explain the psychochemical properties of solute and solvent that affect solubility, stability, and other biopharmaceutical properties in drug dosage forms development. 3. Analyze and interpret data. 4. Design, manufacture and evaluate dosage forms and other drug delivery systems. 5. Able to explain and apply the mechanism of certain drugs at molecular and cellular levels 6. Characterize and evaluate physicochemical properties of the active compounds of natural ingredients 7. Applying separation techniques of natural substances to isolate the active substances and markers. 8. Apply pharmacokinetic processes related to absorption, distribution, metabolism and excretion of drugs 9. Able to explain the important factors required for the design, manufacturing and evaluation of various dosage forms and other drug delivery systems 10. Develop, validate and apply different instrumental analytical techniques to the analysis of medicinal substances in various dosage forms 11. Show contributions in individual or group projects. |
| 6 | Elements of competency | MKK |
| 7 | Type competency | supporting competence |
| 8 | Syllabus | 1. Molecular identification and validation of disease targets; 2-3. Finding Lead Compound from Natural Materials; 4-5. Computer- aided drug design (lead compound discovery); 6-7. Identification and optimization of target interactions and pharmacokinetics optimization; 8. Mid-term Exam; 9-10. Toxicology and safety tests and In vivo and in Vitro tests; 11-12. Pre-formulations and formulations; 13-14. Pre-clinical and clinical trial; 15. Registration and Commercialization |
| 9 | Attribute to soft skills | discipline, communication skill, ethics |
| 10 | Learning methods | ● Discussion ● Audio visual learning |
| 11 | Learning media | LCD |
| 12 | Appraisal | ● Presentation ● Quiz |
| 13 | Lecturer | Apt. Muchtaridi, Ph.D., Prof. Dr. Apt. Moelyono, M.S. Dr. Apt. Keri Lestari, M.Si. and Apt. Taofik Rusdiana, PhD. |
| 14 | References | Raymond G Hill, Humphrey P. Rang. (2021). Drug Discovery and Development. 3rd Edition. Elsevier Donald J. Abraham, Michael Myers. 2021. Burger’s Medicinal Chemistry, Drug Discovery and Development, Volumes 1 – 8, 8th Edition. Wiley-Interscience Dev Bukhsh Singh. 2020. Computer Aided Drug Design. 1th edition. SPRINGER Benjamin Blass. 2015. Basic Principles of Drug Discovery and Development. 1th edition. Elsevier-Academic Press Graham Patrick L. 2017. An Introduction to Medicinal Chemistry. 6th edition. Oxford University Press J. Andrew Williams, Richard Lalonde, Jeffrey R. Koup, David D. Christ, Sean Ekins. (2012). Predictive Approaches in Drug Discovery and Development: Biomarkers and In Vitro / In Vivo Correlations (Wiley Series on Technologies for the Pharmaceutical Industry). Bente Steffansen, Yuichi Sugiyama, Bente Steffansen. (2013). Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation Camille Georges W., David Aldous, Didier Rognan, Pierre Raboisson. (2015). The Practice of Medicinal Chemistry, Fourth Edition |
Course Semester Plan