Researching Apigenin Herba Celery, Sofi Nurmay Stiani Wins Doctoral Degree
[farmasi.unpad.ac.id, 20/1/2021) Lecturer at STIKes Salsabila Serang, Sofi Nurmay Stiani won a Doctorate Degree in the Doctor of Pharmacy Study Program, Padjadjaran University (Unpad). Sofi earned a Doctoral Degree after defending his dissertation entitled “Optimization and Formulation of Apigenin Solid Dispersion Tablets for Celery Herbs (Apiumgraveolens L) with the Hot Melt Extrusion (HME) Method as Anti Calculi” at the Doctoral Promotion Session of the Pharmacy Doctoral Program, Faculty of Pharmacy Unpad, which was carried out in hybrid (combination offline and online) at the Campus Auditorium, Faculty of Pharmacy Unpad, Jatinangor, Wednesday (20/01).
Sofi revealed that the research was carried out in addition to knowing the optimization and preparation of solid dispersions with HME from celery herb apigenin (Apium graveolens L.) which has the best characteristics as well as to test the solubility and dissolution rate of celery herb apigenin (Apiumgraveolens L.) as a result of the dispersion. solid matrix with Kollidon® VA 64 and Soluplus® using the HME (Hot Melt Extrusion) method and designing formulas and evaluating the apigenin tablets resulting from solid dispersion with the best characteristics using the HME (Hot Melt Extrusion) method, as well as testing whether celery herb apigenin (Apium graveolens L .) the result of solid dispersion by HME (Hot Melt Extrusion) method has an anti-calculi effect
In his dissertation, Sofi explained that solid dispersion is a dispersion of one or more active ingredients in an inert carrier or matrix in a solid-state which is prepared by fusion, dissolving, or dissolving fusion methods. Solid dispersion is a way to overcome challenges in the pharmaceutical industry in developing solid dosage forms because almost more than 50% of candidate drugs have poor water solubility.
The technique for making solid dispersions that is rarely used in Indonesia is the HME (Hot Melt Extrusion) technique. This HME (Hot Melt Extrusion) pharmaceutical technology has succeeded in increasing the oral bioavailability of drugs with low solubility. HME is used to disperse the insoluble drug into the hydrophilic matrix at the molecular level including changes in the drug in the amorphous, crystalline, or between amorphous and crystalline forms.
The advantages of the HME technique include a method that is easy to work with, efficient, does not require solvents, can increase the dissolution rate for solid dispersions, mask the bitter taste, can control or modify slow-release preparations, is environmentally friendly, easy to scale up and is used in industrial level, and has been shown to disperse difficult-solubility drug molecules in polymer-carriers as well as to increase dissolution rates and bioavailability. The disadvantages are that it requires a high energy supply, there is still a limited number of polymers that are stable to heat, and not for thermolabile active substances.
This study has provided a solution to the existing problem by making solid dispersions using the HME method from apigenin with a matrix of Kollidon® VA 64 (Vinyl pyrolidone vinyl acetate) and Soluplus®. The best solid dispersion results are formulated in tablet dosage forms. Based on 37 research entitled Suitability of Plasticized Polymers for Hot Melt Extrusion, it was explained that Kollidon® VA 64 and Soluplus® showed the best polymers suitable for HME (Hot Melt Extrusion).
Furthermore, he hopes that this research will open opportunities for further research in the form of pharmacokinetic tests on the results of solid dispersion using the HME (Hot Melt Extrusion) method to see the pharmacokinetic profile in the form of absorption rate constants (ka) peak levels of bioactive compounds in blood (Cmax), elimination rate constants. (to), elimination half-time (T1 / 2), and AUC (Area Under Curve). Other researchers could also develop polymers other than soluplus® and kollidon® VA 64 to modify apigenin using the Hot Melt Extrusion technique and for pharmacological effects other than anti-calculi and a complete stability test was carried out.
In his doctoral research, Sofi has successfully published 3 articles in international journals indexed by Scopus Quartile Rank 3 and 2 as well as 1 registered patent. The Doctoral Promotion Session was chaired by the Dean of the Faculty of Pharmacy Unpad, Prof. Dr. apt., Ajeng Diantini M.Si. The meeting was also attended offline by the chairman of the promoter Sofi, namely apt., Taofik Rusdiana Ph, D.,. While the members of the promoter team are Prof. Dr. Cap., Anas Subarnas M.Sc. The expert opponent team consisted of prof. Dr. Erizal Zaini from Andalas University, Prof. Dr. Sri Adi Sumiwi, Dr. Dolih Gozali, and Prof. Dr. Marline Abdassah M.Si represented the UNPAD Professor who attended the online Doctoral Promotion Session. For this dissertation, Sofi earned a Doctorate with Praise Judicium (wep) *
