The antioxidant activity and cytotoxicity methanol extracts from cranberry plantsThe antioxidant activity and cytotoxicity methanol extracts from cranberry plants

Resmi Mustarichie1*, Zalinar Udin2, Ahmad Muhtadi1, Emma Surahman, Anas Subarnas1 and Supriyatna1.
1 Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia.
2 Indonesian Institute of Sciences, Bandung, Indonesia.
(Received: 04 August, 2012; Accepted: 06 August, 2012; Published: 29 August, 2012)
*Corresponding Author: Email: resmi.mustarichie@unpad.ac.id

ABSTRACT
The purpose of this study was to determine the total phenol content, antioxidant activity and cytotoxicity of methanol extracts from cranberry plants. The highest total phenol content of 17.1 mg/100 g, and antioxidant activity with IC50 = 23.8 mg/100 g. This situation shows that the total content of phenolic plant extracts examined correlated with DPPH activity. IC50 cytotoxicity of methanol extracts of each 75.11 μg/mL against Calu-6 cells, 177.53 from μg/mL against MCF-cells and 54.87 μg/mL against HCT- 116 cells. From the data obtained we can conclude that this plant has a quite high of total phenolic content and antioxidant activity. Correlation between total phenolics increased DPPH free radical scavenging and cytotoxic activities are quite good. The results of this study showed that cranberry plants can be used as the basis for the treatment of some diseases. Key words: cranberry, methanol extracts, natural antioxidants, total phenolics content, activity of DPPH radical scavenger, cytotoxicity activity

avalaible at http://irjpas.com/zip.php?file=File_Folder/Resmi%20Mustarichie%20et%20al%2056-61.pdf&id=76&quat=2 

Resmi Mustarichie1*, Zalinar Udin2, Ahmad Muhtadi1, Emma Surahman, Anas Subarnas1 and Supriyatna1.
1 Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, Indonesia.
2 Indonesian Institute of Sciences, Bandung, Indonesia.
(Received: 04 August, 2012; Accepted: 06 August, 2012; Published: 29 August, 2012)
*Corresponding Author: Email: resmi.mustarichie@unpad.ac.id

ABSTRACT
The purpose of this study was to determine the total phenol content, antioxidant activity and cytotoxicity of methanol extracts from cranberry plants. The highest total phenol content of 17.1 mg/100 g, and antioxidant activity with IC50 = 23.8 mg/100 g. This situation shows that the total content of phenolic plant extracts examined correlated with DPPH activity. IC50 cytotoxicity of methanol extracts of each 75.11 μg/mL against Calu-6 cells, 177.53 from μg/mL against MCF-cells and 54.87 μg/mL against HCT- 116 cells. From the data obtained we can conclude that this plant has a quite high of total phenolic content and antioxidant activity. Correlation between total phenolics increased DPPH free radical scavenging and cytotoxic activities are quite good. The results of this study showed that cranberry plants can be used as the basis for the treatment of some diseases. Key words: cranberry, methanol extracts, natural antioxidants, total phenolics content, activity of DPPH radical scavenger, cytotoxicity activity

avalaible at http://irjpas.com/zip.php?file=File_Folder/Resmi%20Mustarichie%20et%20al%2056-61.pdf&id=76&quat=2

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