Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathwayKaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway

Authors: Ajeng Diantini, Anas Subarnas, Keri Lestari, Eli Halimah, Yasmiwar  Susilawati, Supriyatna Supriyatna, Euis Julaeha, Tri H. Achmad, Eka W. Suradji, Chiho  Yamazaki, Kenji Kobayashi, Hiroshi Koyama, Rizky Abdulah

Affiliations: Division of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia, Division of Pharmacognosy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia, Department of Biochemistry, Faculty of Medicine, University of Padjadjaran, Jatinangor 45363, Indonesia, Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan

Published online on: Thursday, February 9, 2012

Doi: 10.3892/ol.2012.596

Abstract:

Plants consumed by non-human primates represent potential drug sources for human disease management. In this study, we isolated kaempferol-3-O-rhamnoside as an active compound from the leaves of Schima wallichii Korth., a plant commonly consumed by non-human primates. Its anti-cancer activities, including its ability to induce apoptotic mechanisms, were investigated in MCF-7 breast cancer cells. Results showed that in MCF-7 cells, kaempferol-3-O-rhamnoside inhibits cell proliferation in a dose-dependent manner and promotes apoptosis via the activation of the caspase signaling cascade, which includes caspase-9, caspase-3 and PARP. Our results provide a basis for further exploration of kaempferol-3-O-rhamnoside as an active compound for potential anti-cancer therapeutics

http://www.spandidos-publications.com/10.3892/ol.2012.596Authors: Ajeng Diantini, Anas Subarnas, Keri Lestari, Eli Halimah, Yasmiwar  Susilawati, Supriyatna Supriyatna, Euis Julaeha, Tri H. Achmad, Eka W. Suradji, Chiho  Yamazaki, Kenji Kobayashi, Hiroshi Koyama, Rizky Abdulah

Affiliations: Division of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia, Division of Pharmacognosy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor 45363, Indonesia, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor 45363, Indonesia, Department of Biochemistry, Faculty of Medicine, University of Padjadjaran, Jatinangor 45363, Indonesia, Department of Public Health, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan

Published online on: Thursday, February 9, 2012

Doi: 10.3892/ol.2012.596

Abstract:

Plants consumed by non-human primates represent potential drug sources for human disease management. In this study, we isolated kaempferol-3-O-rhamnoside as an active compound from the leaves of Schima wallichii Korth., a plant commonly consumed by non-human primates. Its anti-cancer activities, including its ability to induce apoptotic mechanisms, were investigated in MCF-7 breast cancer cells. Results showed that in MCF-7 cells, kaempferol-3-O-rhamnoside inhibits cell proliferation in a dose-dependent manner and promotes apoptosis via the activation of the caspase signaling cascade, which includes caspase-9, caspase-3 and PARP. Our results provide a basis for further exploration of kaempferol-3-O-rhamnoside as an active compound for potential anti-cancer therapeutics

http://www.spandidos-publications.com/10.3892/ol.2012.596

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