In Vitro Permeation Studies of Nicotine Patch Based on HPMC and Ethylcellulose

Soraya Ratnawulan Mita1,Lucy DN Sasongko2, Yoseph I Sigit2
1Pharmaceutic Division, Faculty of Pharmacy, Universitas Padjadjaran
Jl. Raya Bandung Sumedang KM.21, West Java, Bandung, Indonesia 45363
2School of Pharmacy, Institut Teknologi Bandung
Presented in PSCE 2010

Nicotine patch is one of alternative therapies to stop smoking.  The aim of study is to formulated and evaluated nicotine patch. Nicotine patch (48.285 mg/patch) was formulated by  using hidroxymethylcellulose and ethylcellulose 5% (4:1), isopropyl miristate (10%) as an enhancher, dibuthylphtalate as a plasticizier (1,25%), and polyisobutlene (2,5% in n-hexane) as an adhesive, and combination of methanol and chloroform (1:1) as solvents.  In vitro permeability of nicotine was evaluated using the horizontal type of flow-through diffusion cells for 24 h and shed snake skin of Phyton reticulate as the membrane. The irritation study was done in a dorsal area of rabbits. The results of in vitro permeation of nicotine  was 6.19% ± 3.03% and 9.21% ± 1.30% from the tested patch and commercial preparation, respectively. The nicotine patch have not give irritation or udem sign. In vitro permeation of nicotine patch showed similar profiles with commercial preparation but in lower amount. Mechanism of permeation released of nicotine from the patch  followed  Higuchi kinetic equation.

Keywords : Patch, Nicotine, In vitro

Soraya Ratnawulan Mita1,Lucy DN Sasongko2, Yoseph I Sigit2
1Pharmaceutic Division, Faculty of Pharmacy, Universitas Padjadjaran
Jl. Raya Bandung Sumedang KM.21, West Java, Bandung, Indonesia 45363
2School of Pharmacy, Institut Teknologi Bandung
Presented in PSCE 2010

Nicotine patch is one of alternative therapies to stop smoking.  The aim of study is to formulated and evaluated nicotine patch. Nicotine patch (48.285 mg/patch) was formulated by  using hidroxymethylcellulose and ethylcellulose 5% (4:1), isopropyl miristate (10%) as an enhancher, dibuthylphtalate as a plasticizier (1,25%), and polyisobutlene (2,5% in n-hexane) as an adhesive, and combination of methanol and chloroform (1:1) as solvents.  In vitro permeability of nicotine was evaluated using the horizontal type of flow-through diffusion cells for 24 h and shed snake skin of Phyton reticulate as the membrane. The irritation study was done in a dorsal area of rabbits. The results of in vitro permeation of nicotine  was 6.19% ± 3.03% and 9.21% ± 1.30% from the tested patch and commercial preparation, respectively. The nicotine patch have not give irritation or udem sign. In vitro permeation of nicotine patch showed similar profiles with commercial preparation but in lower amount. Mechanism of permeation released of nicotine from the patch  followed  Higuchi kinetic equation.

Keywords : Patch, Nicotine, In vitro

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