CHEMICAL COMPOSITION AND LOCOMOTOR ACTIVITY OF ANDALIMAN FRUITS (ZANTHOXYLUM ACANTHOPODIUM DC.) ESSENTIAL OIL ON MICE

MOELYONO MOEKTIWARDOYO, MUCHTARIDI MUCHTARIDI, ELI HALIMAH

ABSTRACT 

Introduction: Andaliman (Zanthoxylum acanthopodium DC.) is spices from North Sumatra that have potent as aromatherapy material.
Objective: The objective study is to evaluate the inhibitory effect of Andaliman (Zanthoxylum acanthopodium DC.) fruits essential oil on the locomotor activity of mice in a wheel cage
Methods: The study on analysing of essential oil compounds of andaliman fruits using GC-MS method and locomotor activity on mice has been carried out. The locomotor activity was tested by wheel cage methods.
Results: The results of GC-MS analysis showed that there were 29 compounds identified in fruits of andaliman’s essential oil with some major compounds such as geranyl acetate, citronella, β-citronelol, nerol, limonene, geraniol, caryophyllene, citronellyl acetate, and α-pinene by LRI index confirmation. The locomotor activity showed that the inhalation of essential oil andliman fruits at 0.1 mL a dose decreased the locomotor acivity as much as 9.67 %, while at 0.3 and 0.5 mL doses increased the locomotor activity as much as 0.62 % and 3.95 %.
Conclusion: This study could conclude that inhalation of andaliman fruits essential oil gave different influence to locomotor activity depended given doses.
Keywords: Andaliman, Zanthoxylum acanthopodium DC, Locomotor Activity, Aromatherapy.

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