Antiplasmodial and other constituents from four Indonesian Garcinia spp.Antiplasmodial and other constituents from four Indonesian Garcinia spp.

Elfita Elfitaa, Muharni Muharnia, Madyawati Latiefb, Darwati Darwatic, Ari Widiyantorod, Supriyatna Supriyatnae, Husein H. Bahtic, Dachriyanus Dachriyanusf, Paul Cosg, Louis Maesg, Kenne Fouberth, Sandra Apersh, Luc Pietersh

a Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Palembang, Indonesia
b Faculty of Agriculture, University of Jambi, Jambi, Indonesia
c Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Bandung, Indonesia
d Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tanjungpura University, Pontianak, Indonesia
e Faculty of Pharmacy, Padjadjaran University, Bandung, Indonesia
f Faculty of Pharmacy, Andalas University, Padang, Indonesia

 

g Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Belgium
h Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Belgium

Received 12 February 2009; revised 29 April 2009; Accepted 30 April 2009. Available online 27 May 2009.

Abstract

Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, β-sitosterol-3-O-β-d-glucoside and stigmasterol-3-O-β-d-glucoside from the stem bark of G. griffithii; friedelin and 3β-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (±)-morelloflavone, morelloflavone-7-O-β-d-glucoside or fukugiside, the triterpene 3β-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene β-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity.

Available at www.sciencedirect.com/science/article/pii/S0031942209001770Elfita Elfitaa, Muharni Muharnia, Madyawati Latiefb, Darwati Darwatic, Ari Widiyantorod, Supriyatna Supriyatnae, Husein H. Bahtic, Dachriyanus Dachriyanusf, Paul Cosg, Louis Maesg, Kenne Fouberth, Sandra Apersh, Luc Pietersh, ,

a

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Palembang, Indonesia

b

Faculty of Agriculture, University of Jambi, Jambi, Indonesia

c

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Bandung, Indonesia

d

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Tanjungpura University, Pontianak, Indonesia

e

Faculty of Pharmacy, Padjadjaran University, Bandung, Indonesia

f

Faculty of Pharmacy, Andalas University, Padang, Indonesia

g

Laboratory of Microbiology, Parasitology and Hygiene, Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Belgium

h

Laboratory of Pharmacognosy and Pharmaceutical Analysis, Department of Pharmaceutical Sciences, University of Antwerp, Belgium

Received 12 February 2009; revised 29 April 2009; Accepted 30 April 2009. Available online 27 May 2009.

Abstract

Phytochemical investigations of four Garcinia spp. from Indonesia, i.e. Garcinia griffithii T. Anderson, Garcinia celebica L., Garcinia cornea L. and Garcinia cymosa K. Schum (Clusiaceae), have resulted in the isolation of a xanthone, 1,5-dihydroxy-3,6-dimethoxy-2,7-diprenylxanthone, 1,7-dihydroxyxanthone, isoxanthochymol, β-sitosterol-3-O-β-d-glucoside and stigmasterol-3-O-β-d-glucoside from the stem bark of G. griffithii; friedelin and 3β-hydroxy-23-oxo-9,16-lanostadien-26-oic acid or garcihombronane D from leaves of G. celebica; 23-hydroxy-3-oxo-cycloart-24-en-26-oic acid and epicatechin from stem bark of G. cornea; (±)-morelloflavone, morelloflavone-7-O-β-d-glucoside or fukugiside, the triterpene 3β-hydroxy-5-glutinen-28-oic acid and canophyllol from stem bark of G. cymosa. The xanthone and garcihombronane D displayed a selective activity against Plasmodium falciparum; isoxanthochymol and the triterpene β-hydroxy-5-glutinen-28-oic acid a broad but non-selective antiprotozoal activity.

Available at www.sciencedirect.com/science/article/pii/S0031942209001770

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